Drug design research papers

Some researchers apply a narrow approach to "explanation." In this view, an explanation is contextualized to only a particular case in a particular time and place, and thus generalization is considered inappropriate. In fact, an over-specific explanation might not explain anything at all. For example, if one asks, "Why Alex Yu behaves in that way," the answer could be "because he is Alex Yu. He is a unique human being. He has a particular family background and a specific social circle." These "particular" statements are always right, thereby misguide researchers away from the issue of external validity.

Design research ‘came of age’ in the 1980s, and has continued to expand. This was helped by the development of a research base, including doctoral programmes, within many of the design schools located within new institutions that were previously art colleges, and the emergence of new areas such as interaction design. More new journals have appeared, such as The Design Journal , the Journal of Design Research , CoDesign and more recently Design Science . There has also been a major growth in conferences, with not only a continuing series by DRS, but also series such as Design Thinking, Doctoral Education in Design, Design Computing and Cognition, Design and Emotion, the European Academy, the Asian Design Conferences, etc. Design research now operates on an international scale, acknowledged in the cooperation of DRS with the Asian design research societies in the founding in 2005 of the International Association of Societies of Design Research.

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Structure-based drug design attempts to use the structure of proteins as a basis for designing new ligands by applying the principles of molecular recognition . Selective high affinity binding to the target is generally desirable since it leads to more efficacious drugs with fewer side effects. Thus, one of the most important principles for designing or obtaining potential new ligands is to predict the binding affinity of a certain ligand to its target (and known antitargets ) and use the predicted affinity as a criterion for selection. [39]

Drug design research papers

drug design research papers

Structure-based drug design attempts to use the structure of proteins as a basis for designing new ligands by applying the principles of molecular recognition . Selective high affinity binding to the target is generally desirable since it leads to more efficacious drugs with fewer side effects. Thus, one of the most important principles for designing or obtaining potential new ligands is to predict the binding affinity of a certain ligand to its target (and known antitargets ) and use the predicted affinity as a criterion for selection. [39]

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